Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide
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چکیده
منابع مشابه
Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.
Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid α-galactosylceramide (α-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. We synthesized a novel thioglycoside analogue of α-GalCer, denoted α-S-GalCer, and tested its efficacy for stimulating human iNKT cells in vitro. α-S-GalCer stimulated cytokin...
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Natural killer dendritic cells (NKDCs) possess potent anti-tumor activity, but the cellular effect of NKDC interactions with other innate immune cells is unclear. In this study, we demonstrate that the interaction of NKDCs and natural killer T (NKT) cells is required for the anti-tumor immune responses that are elicited by α -galactosylceramide ( α -GC) in mice. The rapid and strong expression ...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2011
ISSN: 1521-6616
DOI: 10.1016/j.clim.2011.03.016